TOP 100 Villains (41-50)

Number 50: Starscream
Origin: Transformers
Nemesis: Optimus Prime, Megatron

Number 49: Cobra Commander
Origin: G.I. Joe
Nemesis: Duke

Number 48: Carnage
Origin: Spider-Man
Nemesis: Spider-Man, Venom

Number 47: Him
Origin: Powerpuff Girls
Nemesis: Powerpuff Girls

Number 46: Saruman
Origin: Lord of the Rings
Nemesis: Gandalf

Number 45: Daolon Wong
Origin: Jackie Chan Adventures
Nemesis: Uncle, Master Fong

Number 44: Marik Ishtar
Origin: Yu-Gi-Oh
Nemesis: Yugi, Pharaoh Atem

Number 43: Mr. Burns
Origin: The Simpsons
Nemesis: Maggie Simpson

Number 42: James Moriarty
Origin: Sherlock Holmes
Nemesis: Sherlock Holmes

Number 41: Skeletor
Origin: He-Man
Nemesis: He-Man

Selections By:
Giuliano V.
Matteo C.
Gino C.
Justin D.
Riley D.
               

TOP 100 Villains (51-60)

Number 60: Lavos
Origin: Chrono Trigger
Nemesis: Magus, Crono

Number 59: Chief Blue Meanie
Origin: Yellow Submarine
Nemesis: The Beatles

Number 58: Xehanort
Origin: Kingdom Hearts
Nemesis: Sora, Riku, Aqua, Terra, Ventus

Number 57: Dr. Evil
Origin: Austin Powers
Nemesis: Austin Powers

Number 56: Chaos
Origin: Final Fantasy
Nemesis: Cosmos

Number 55: M. Bison
Origin: Street Fighter
Nemesis: Ryu, Ken

Number 54: Ra's al Ghul
Origin: Batman
Nemesis: Batman

Number 53: Galactus
Origin: Fantastic Four
Nemesis: Fantastic Four, Silver Surfer

Number 52: Darkseid
Origin: Superman
Nemesis: Superman

Number 51: Wario
Origin: Super Mario
Nemesis: Mario

Selections By:
Giuliano V.
Matteo C.
Gino C.
Justin D.
Riley D.
               

TOP 100 Villains (61-70)

Number 70: Jafar
Origin: Aladdin
Nemesis: Aladdin

Number 69: Revolver Ocelot
Origin: Metal Gear Solid
Nemesis: Solid Snake

Number 68: Andross
Origin: Star Fox
Nemesis: Team Star Fox

Number 67: Lord Dark Helmet  
Origin: Spaceballs
Nemesis: Lone Starr

Number 66: Doctor Robotnik AKA Eggman
Origin: Sonic the Hedgehog
Nemesis: Sonic the Hedgehog

Number 65: Mandark
Origin: Dexter's Lab
Nemesis: Dexter

Number 64: Deathstroke
Origin: Teen Titans
Nemesis: Green Arrow

Number 63: Kessler
Origin: inFamous
Nemesis: Cole MacGrath, The Beast

Number 62: Dark Phoenix
Origin: X-Men
Nemesis: The X-Men

Number 61: Mankar Cameron
Origin: The Elder Scrolls
Nemesis: The Hero of Kvatch

Selections By:
Giuliano V.
Matteo C.
Gino C.
Justin D.
Riley D.           

TOP 100 Villains (71-80)

Number 80: Vergil
Origin: Devil May Cry
Nemesis: Dante

Number 79: Porky
Origin: EarthBound/MOTHER
Nemesis: Ness, Lucas

    
Number 78: The Mandarin
Origin: Iron Man
Nemesis: Iron Man

Number 77: Plankton
Origin: SpongeBob SquarePants
Nemesis: Mr. Krabs

Number 76: Doctor Nefarious
Origin: Ratchet & Clank
Nemesis: Ratchet, Clank, Qwark

Number 75: Loki
Origin: Thor
Nemesis: Thor

Number 74: Braniac
Origin: Superman
Nemesis: Superman

Number 73: Timmy the Evil
Origin: Unforgotten Realms
Nemesis: Sir Schmoopy of Awesometon

Number 72: Warren Vidic
Origin: Assassin's Creed
Nemesis: Desmond Miles, William Miles

Number 71: Jigsaw
Origin: Saw
Nemesis: Detective David Tapp

Selections By:
Giuliano V.
Matteo C.
Gino C.
Justin D.
Riley D.
               

TOP 100 Villains (81-90)

Number 90: Slender-Man
Origin: Slender
Nemesis: Not Specified

Number 89: Saix
Origin: Kingdom Hearts
Nemesis: Sora, Roxas, Axel

Number 88: Kingpin
Origin: Spider-Man
Nemesis: Daredevil, Spider-Man

Number 87: Ursula the Sea Witch
Origin: The Little Mermaid
Nemesis: Ariel, King Triton

    
Number 86: Rodrigo Borgia
Origin: Assassin's Creed
Nemesis: Ezio Auditore

Number 85: Khan
Origin: Star Trek
Nemesis: Captain Kirk

Number 84: Ridley
Origin: Metroid
Nemesis: Samus Aran

Number 83: Goldfinger
Origin: James Bond 007
Nemesis: James Bond  

Number 82: Master Hand
Origin: Super Smash Bros.
Nemesis: Various Nintendo Characters

Number 81: Dr. Wily
Origin: Mega Man
Nemesis: Mega Man, Dr. Light

Selections By:
Giuliano V.
Matteo C.
Gino C.
Justin D.
Riley D.